Ran into an issue with an application that was hitting the maximum Header Size in the request. F5 default size is 32k and when an app hits a limit it looks like this

So can you up the size?
The answer isn’t as simple as you think it may be since the F5 isn’t the only device in the path of the application. Example if you use a CDN the traffic would hit a limit there as well and the Web App Server also has a limit. If it has been proven everywhere else accepts a larger size then you just need to update the HTTP profile

F5 KB Article Reference: K8482